 |
A calreticulin-like protein from endoparasitoid venom fluid is involved in host hemocyte inactivation
Zhang, G. M., Schmidt, O. and Asgari, S. (2006) A calreticulin-like protein from endoparasitoid venom fluid is involved in host hemocyte inactivation. Developmental And Comparative Immunology, 30 9: 756-764.
|
|
|
| Author(s) |
Zhang, G. M.
Schmidt, O.
Asgari, S.
|
| Title |
A calreticulin-like protein from endoparasitoid venom fluid is involved in host hemocyte inactivation
|
| Journal name |
Developmental And Comparative Immunology
|
| Publication date |
2006
|
| Volume number |
30
|
| Issue number |
9
|
| ISSN |
0145-305X
|
| Start page |
756
|
| End page |
764
|
| Total pages |
9
|
| Editor(s) |
Dr. GW Warr; Dr. LW Clem; and K. Soderhall
|
| Place of publication |
Oxford
|
| Publisher |
Pergamon-Elsevier Science Ltd
|
| Collection year |
2006
|
| Subject |
C1
270504 Invertebrate Biology
780105 Biological sciences
|
| Abstract |
During oviposition, most endoparasitoid wasps inject maternal factors into their hosts to interfere with host immune reactions and ensure successful development of their progeny. Since encapsulation is a major cellular defensive response of insects against intruding parasites, parasitoids have developed numerous mechanisms to suppress the host encapsulation capability by interfering with every step in the process, including recognition, adherence and spreading. In previous studies, components of Cotesia rubecula venom were shown to inhibit melanization of host hemolymph by interfering with the prophenoloxidase activation cascade and facilitate expression of polydnavirus genes. Here we report the isolation and characterization of another venom protein with similarity to calreticulin. Results indicate that C rubecula calreticulin (CrCRT) inhibits hemocyte spreading behavior, thus preventing encapsulation of the developing parasitoid. It is possible that the protein might function as an antagonist competing for binding sites with the host hemocyte calreticulin, which mediates early-encapsulation reactions. (c) 2005 Elsevier Ltd. All rights reserved.
|
| Keyword(s) |
Cotesia Rubecula
Pieris Rapae
Venom
Calreticulin
Immune Suppression
Encapsulation
Hemocyte Spreading
Immunology
Zoology
Cell-surface Calreticulin
Pseudaletia-separata Walker
Apanteles-kariyai Watanabe
Cotesia-rubecula
Pieris-rapae
Immunoglobulin Superfamily
Immune-response
Insect
Polydnavirus
Activation
|
|
|
